New way to combat multidrug-resistant ‘superbugs’ revealed

The golden age of antibiotics is on its way after several gold-based compounds were found to have the potential to treat multidrug-resistant “superbugs.”

With 19 of the compounds testing effective against at least one hard-to-treat bacterium and some effective against multiple, the future is looking golden.

Drug-resistant infections kill an estimated 700,000 people a year globally and this figure is projected to rise to 10 million by 2050 if no action is taken.

The World Health Organization classes antibiotic resistance as one of the greatest public health threats facing humanity.

However, the development of new antibiotics has stalled and the few new antibiotics being developed are mainly offshoots of existing treatments.

Gold is known to have antibacterial properties, making it an exciting new potential.

The gold metalloantibiotics are compounds with a gold ion at their core and, according to researchers are inexpensive and straightforward to make.

The study investigated 19 gold complexes against a range of multidrug-resistant bacteria.

The complexes all belong to the same family but have slightly different structures.

The team studied six bacteria includin Methicillin-resistant Staphylococcus aureus, which causes MRSA, Staphylococcus epidermidis, which causes catheter-associated infections, and Pseudomonas aeruginosa, which leads to infections such as pneumonia.

The other three were Stenotrophomonas maltophilia, which can also cause pneumonia and Acinetobacter baumannii and Escherichia coli that leads to blood and urinary tract infections as well as pneumonia.

All the strains studied were multi-drug resistant.

S. aureus, P. aeruginosa, A. baumannii and E. coli are among the bacteria judged to pose the greatest risk to human health.

Multidrug-resistant S. maltophilia is increasingly being found in the lungs of people with cystic fibrosis.

In the tests, 84 percent of the gold complexes were highly effective against MRSA and S. epidermis.

Out of the 19 complexes 16 were effective against the other bacteria, all of which have greater inbuilt resistance to antibiotics.

Gold complexes use a variety of techniques to kill bacteria.

They stop enzymes from working, disrupt the function of the bacterial membrane and damage DNA.

Crucially, these new antibiotics should prevent antimicrobial resistance from developing.

Study author Dr. Sara Soto González, from Barcelona Institute for Global Health in Spain, said: “All of the gold compounds were effective against at least one of the bacterial species studied and some displayed potent activity against several multidrug-resistant bacteria.

“It is particularly exciting to see that some of the gold complexes were effective against MRSA and multidrug-resistant A. baumannii, as there are two biggest causes of hospital-acquired infections.

“The type of gold complexes we studied, known as gold (III) complexes, are relatively straightforward and inexpensive to make. They can also be easily modified and so provide a vast amount of scope for drug development.”

She added:

“With research on other types of gold metalloantibiotics also providing promising results, the future is bright for gold-based antibiotics.”

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