{"id":535545,"date":"2023-04-10T20:11:26","date_gmt":"2023-04-11T02:11:26","guid":{"rendered":"https:\/\/cerebrodigital.net\/nueva-forma-de-combatir-las-superbacterias-resistentes-a-multiples-farmacos-revelada-eacr\/"},"modified":"2023-07-02T19:48:54","modified_gmt":"2023-07-03T01:48:54","slug":"new-way-to-combat-multidrug-resistant-superbugs-revealed-eacr","status":"publish","type":"post","link":"https:\/\/cerebrodigital.net\/en\/new-way-to-combat-multidrug-resistant-superbugs-revealed-eacr\/","title":{"rendered":"New way to combat multidrug-resistant \u2018superbugs\u2019 revealed"},"content":{"rendered":"\n

The golden age of antibiotics is on its way after several gold-based compounds were found to have the potential<\/a> to treat multidrug-resistant \u201csuperbugs.\u201d<\/p>\n\n\n\n

\"-\"<\/figure>\n\n\n\n

With 19 of the compounds testing effective against at least one hard-to-treat bacterium and some effective against multiple, the future is looking golden.<\/p>\n\n\n\n

Drug-resistant infections kill an estimated 700,000 people a year globally and this figure is projected to rise to 10 million by 2050 if no action is taken.<\/p>\n\n\n\n

The World Health Organization classes antibiotic resistance as one of the greatest public health threats facing humanity.<\/p>\n\n\n\n

However, the development of new antibiotics has stalled and the few new antibiotics being developed are mainly offshoots of existing treatments.<\/p>\n\n\n\n

Gold is known to have antibacterial properties, making it an exciting new potential.<\/p>\n\n\n\n

The gold metalloantibiotics are compounds with a gold ion at their core and, according to researchers are inexpensive and straightforward to make.<\/p>\n\n\n\n

The study investigated 19 gold complexes against a range of multidrug-resistant bacteria.<\/p>\n\n\n\n

The complexes all belong to the same family but have slightly different structures.<\/p>\n\n\n\n

The team studied six bacteria includin Methicillin-resistant Staphylococcus aureus, which causes MRSA, Staphylococcus epidermidis, which causes catheter-associated infections, and Pseudomonas aeruginosa, which leads to infections such as pneumonia.<\/p>\n\n\n\n

The other three were Stenotrophomonas maltophilia, which can also cause pneumonia and Acinetobacter baumannii and Escherichia coli that leads to blood and urinary tract infections as well as pneumonia.<\/p>\n\n\n\n

\"-\"<\/figure>\n\n\n\n

All the strains studied were multi-drug resistant.<\/strong><\/p>\n\n\n\n

S. aureus, P. aeruginosa, A. baumannii and E. coli are among the bacteria judged to pose the greatest risk to human health.<\/p>\n\n\n\n

Multidrug-resistant S. maltophilia is increasingly being found in the lungs of people with cystic fibrosis.<\/p>\n\n\n\n

In the tests, 84 percent of the gold complexes were highly effective against MRSA and S. epidermis.<\/p>\n\n\n\n

Out of the 19 complexes 16 were effective against the other bacteria, all of which have greater inbuilt resistance to antibiotics.<\/p>\n\n\n\n

Gold complexes use a variety of techniques to kill bacteria.<\/p>\n\n\n\n

They stop enzymes from working, disrupt the function of the bacterial membrane and damage DNA.<\/p>\n\n\n\n

Crucially, these new antibiotics should prevent antimicrobial resistance from developing.<\/p>\n\n\n\n

Study author Dr. Sara Soto Gonz\u00e1lez, from Barcelona Institute for Global Health in Spain, said: \u201cAll of the gold compounds were effective against at least one of the bacterial species studied and some displayed potent activity against several multidrug-resistant bacteria.<\/em><\/p>\n\n\n\n

\u201cIt is particularly exciting to see that some of the gold complexes were effective against MRSA and multidrug-resistant A. baumannii, as there are two biggest causes of hospital-acquired infections.<\/em><\/p>\n\n\n\n

\u201cThe type of gold complexes we studied, known as gold (III) complexes, are relatively straightforward and inexpensive to make. They can also be easily modified and so provide a vast amount of scope for drug development.”<\/em><\/p>\n\n\n\n

She added:<\/p>\n\n\n\n

\u201cWith research on other types of gold metalloantibiotics also providing promising results, the future is bright for gold-based antibiotics.\u201d<\/em><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

The golden age of antibiotics is on its way after several gold-based compounds were found to have the potential to […]<\/p>\n","protected":false},"author":32,"featured_media":535539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"two_page_speed":[],"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[107106,107252,107085,107208],"tags":[109799,108668,108669,107225,108670],"class_list":["post-535545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine-en","category-science","category-social-science","tag-chemistry","tag-drugs","tag-endurance-2","tag-humans","tag-superbugs"],"jetpack_sharing_enabled":true,"jetpack_likes_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/pdR79Q-2fjP","jetpack-related-posts":[{"id":596554,"url":"https:\/\/cerebrodigital.net\/en\/ancient-disease-is-rapidly-becoming-resistant-to-antibiotics-making-it-more-lethal-than-ever\/","url_meta":{"origin":535545,"position":0},"title":"Ancient disease is rapidly becoming resistant to antibiotics, making it more lethal than ever","author":"Erick Sumoza","date":"May 12, 2025","format":false,"excerpt":"A once nearly eradicated disease surges back, now more dangerous:\u00a0antibiotic resistance. 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